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With a variety of itineraries, ships, and theme cruises to choose from, enjoy the Mississippi River cruise of your dreams with American Cruise Lines. Be treated to award-winning enrichment and gracious, personalized service.

It’s possible to choose the Mississippi River Cruise that’s perfect for you with American Cruise Lines, which offers a variety of Mississippi itineraries ranging in length from 5-22 days and available along the entire length of the river from New Orleans, LA to St. Paul, MN.

On the Lower Mississippi, explore the region’s grand southern plantations, stately antebellum houses, and Civil War battlefields. As you travel to the birthplace of Jazz, Blues, and Rock–n-Roll, taste the finest Cajun and Creole and enjoy mouth-watering Memphis BBQ.

Cruising up the river, hometown Americana takes center stage. Relive the adventures of Mark Twain’s time on a trolley ride through Hannibal, his boyhood hometown. Experience the legacy of John Deere in Davenport and the Victorian-era elegance of Dubuque. As we continue north, pasture gives way to forest and the wildlife of Minnesota and Wisconsin comes into view.

From the vibrant cultural center of the “Big Easy” to the dramatic landscapes of the Upper Mississippi, experience life as it once was on the western frontier. Along the way, be treated to delicious cuisine of the region, award-winning onboard and onshore enrichment, and an unrivalled level of personalized service.

American’s Fleet
Cruise in perfect comfort aboard the most modern riverboats in the region. Select from a variety of ships, including the brand new American Harmony, the second in our revolutionary riverboat series, and American Jazz, coming in the summer of 2020. If a Victorian-style riverboat is more your style, get on board America or Queen of the Mississippi.

No matter which riverboat style you choose, enjoy the largest staterooms in the industry, most with furnished private balconies, a variety of spacious lounges, and all the modern amenities today’s traveler has come to expect.

Mississippi Theme Cruises
Our Mississippi Theme cruises offer something for everyone. On our Civil War theme cruise, delve deep into the history of this defining time in American History as you explore battlefields, monuments, and museums. On our Mark Twain cruise, discover the river that served as the inspiration for this beloved author, complete with an onboard, true-to-life impersonator.

Our Culinary Cruise along the Lower Mississippi River cruise is perfect for food lovers who relish the blend of American, French, and deep South influences on dishes native to the region. Our Music Cruise pays tribute to the musicians and regions that helped influence the birth of American music.

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